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MagNA Lyser Instrument

Conforms to the European directive for in vitro diagnostic medical devices 98/79/EC. For USA: For general laboratory use.

Product No. Pack Size
03358968001 1 instrument (110 V)
Product No. Pack Size
03358976001 1 instrument (220 V)

To order these products, please contact your Roche order management team.

The MagNA Lyser Instrument is a benchtop device that automatically disrupts cells or other biological materials. The instrument facilitates the production of a supernatant containing nucleic acids and proteins suitable for subsequent purification, extraction, or analysis.The instrument is optimized for use with all MagNA Pure Systems, to extract DNA, RNA, or mRNA from different tissue sources. It can also be used for other applications in which tissue and cell disruption is required. This instrument performs efficient homogenization of mammalian tissue, plant tissue, or other materials.Optimized lysis buffers of the different MagNA Pure kits process various sample materials and are available separately. A customized Rotor Cooling Block is included to efficiently cool samples during setup.

Simplify labor-intensive sample preparation

  • Efficiently homogenize a wide variety of sample materials.
  • Prevent nucleic acid degradation with the benchtop cooling block.
  • Ease your setup and cleanup with a removable rotor and prefilled disposable vials.

Automate with an easy-to-use instrument

  • Homogenize up to 16 samples in just a few seconds.
  • Save valuable lab space with a small benchtop instrument.
  • Integrate your workflow with the automated nucleic acid isolation of the MagNA Pure 96, MagNA Pure LC 2.0, and the MagNA Pure Compact Systems.

Save time with versatile, efficient, and rapid pre-preparation

  • Perform consistent and reproducible sample disruption.

The MagNA Lyser Instrument is used for automated, efficient homogenization of tissue samples for different extraction applications. This benchtop instrument perfectly integrates into your laboratory workflow as the initial cell or tissue disruption step before extraction of nucleic acids and further downstream applications, such as real-time PCR or sequencing.

Instrument Specifications

Type Benchtop instrument
Dimensions 30 cm x 31.5 cm x 38 cm 
12 in x 15 in x 11 in
(W x D x H)
Weight Approximately 20 kg (44.1 lbs)
Capacity Quick-release rotor with 1 - 16 positions
Speed Approximately 7,000 rpm
Power Source AC 110 - 240 V, 50/60 Hz
Power Consumption Max. 1 kW


The MagNA Lyser Instrument contains a convenient removable rotor, which holds 16 sample tubes for simultaneous processing. The sample tubes are prefilled with ceramic beads (MagNA Lyser Green Beads); tissue and lysis reagents are added to the sample tubes.
The instrument creates a rapid, oscillating reciprocal motion of the rotor, which agitates the contents of the sample tubes; tissue disruption is caused by the collision of the beads with the sample material. The cells in the sample tubes are disrupted nearly instantaneously when they collide with the ceramic and/or glass beads. The rate of collision and energy of impact (both of which determine the effectiveness of the disruption process) depend on the shaking speed of the instrument and the specific gravity of the beads. By varying both of these parameters, you can ensure optimal disruption of a wide variety of cells. The time of the run can also be varied to disrupt different types of tissue efficiently.

MagNA Lyser Instrument workflow