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Detection of High-Frequency and Novel DNMT3A Mutations in Acute Myeloid Leukemia by High-Resolution Melting Curve Analysis
The Journal of Molecular Diagnostics, 14, 4, Pages 336-345
A rapid high-throughput method for the detection and quantification of RNA editing based on high-resolution melting of amplicons
Nucleic Acids Res, 35, 17, e114 -
Transfering PCRs to HRM-assays on the LightCycler® 480 System - Examples for BRCA1
To evaluate how easy it is to design hrMCA assays using the LightCycler® 480 Instrument, we selected 3 different gene fragments, designed an MCA assay, and tested its sensitivity to detect known variants.
LightCycler® 480 Real-Time PCR System - High Resolution Melting: Optimization Strategies
High resolution melting (HRM) is a novel, closed-tube, post-PCR technique allowing genomic researchers to easily analyze genetic variations in PCR amplicons.
Rapid High-Throughput Methylation Analysis Using the LightCycler® 480 System
We assessed the performance of the instrument combined with the LightCycler® 480 High Resolution Melting Master mix for DNA methylation analysis using the methylation-sensitive high resolution melting (MS-HRM) methodology.
High Resolution Melting: Optimization Strategies
This technical note describes general steps of setting up HRM-based PCR assays, with a special focus on ways how to optimize procedures for gene scanning experiments
Rapid and Reliable Methylation Detection in Archival Tissue Samples using High-Resolution Melting Analysis
The aim of the present study was to establish and evaluate HRM assays for detection of promoter methylation on archival FFPE tissues from individuals with colorectal cancer.