MagNA Pure 24 Instrument
A fully-automated clinical nucleic acid extraction system that brings you walkaway automation for up to 24 samples.
For in vitro diagnostic use.
Product No. | Pack Size |
---|---|
07290519001 | 1 instrument, built-in control unit, and accessories |
To order these products, please contact your Roche order management team.
The MagNA Pure 24 System purifies nucleic acids from a wide range of starting materials using magnetic glass particle technology. The MagNA Pure 24 System builds on the legacy of the MagNA Pure automated nucleic acid extraction systems and processes up to 24 samples in just over an hour using barcoded, prefilled cassettes with ready-to-use reagents.
Preprogrammed software protocols are tailored to a diversity of prevalidated human sample types. The isolated and purified nucleic acids meet the quality standards required for genomic workflows such as highly sensitive quantitative PCR/RT-PCR analysis.
This system enhances your nucleic acid isolation workflow with easy-to-use features such as mixed-sample batching for multiple downstream applications, plus;
- Scalable extraction of 1-24 samples with primary sample
- A single universal reagent kit covering 10 prevalidated human samples types, with volume inputs ranging 200 µL to 4 mL
- Inventory and sample tracking
- True walkaway automation with safety surveillance features
- Seamless data management using intuitive features, such as the link to a laboratory information management system (LIMS).
The MagNA Pure 24 System gives you the flexibility to extract a large variety of human sample types with a single universal reagent kit. Rely on this simplified reagent concept and choose one of the pre-optimized and pre-programmed protocols to extract from mixed batch sample types and primary tubes within one protocol. Please refer to the MagNA Pure 24 protocol download instructions found here.
The following protocols have been updated:
- hgDNA 200 Version 3.1
- Fast hgDNA 200 Version 3.1
- hgDNA ds 200 Version 3.1
- Pathogen 200 Version 3.1
- Pathogen 1000 Version 3.1
- External Lysis Pathogen 500 Version 2.0
- Sample Transfer Version 3.1
In order to be able to access the new protocols listed above, the sequence of setting is as follow:
- Step 1: select reagent cassette of "Total NA Isolation Kit 1.1"
- Step 2: select sample type
- Step 3: select sample volume
- Step 4: select protocol
Target: Bacterial, fungal and viral NA | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Protocol name | Input sample type and sample volumes | Elution volume | ||||||||
Whole blood | Plasma | Serum | Nasal swabs‡ | BAL§ |
Urine | Stool | Cultured cells | Fresh-frozen tissue | ||
200 μL | 200 μL | 200 μL | 200 μL | 200 μL | 200 μL | 200 μL | 50 or 100 μL |
|||
Fast Pathogen 200 |
200 μL |
200 μL |
200 μL |
200 μL |
200 μL |
200 μL |
200 μL |
50 or 100 μL |
||
500 or 1000 μL |
500 or 1000 μL |
500 or 1000 μL |
500 or 1000 μL |
500 or 1000 μL |
500 or 1000 μL |
500 or 1000 μL |
50 or 100 μL |
|||
External Lysis Pathogen 200 Protocol optimized with external lysis buffer |
200 μL |
200 μL |
200 μL |
50 or 100 μL |
||||||
External Lysis Pathogen 500 Protocol optimized with external lysis buffer |
500 μL |
500 μL | 500 μL | 50 or 100 μL |
||||||
‡Nasal swabs=Nasopharyngeal/nasal swabs §BAL=Bronchoalveolar Lavage |
Target: Genomic DNA | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Protocol name | Input sample type and sample volumes | Elution volume | |||||||||
Whole blood | Plasma | Serum | Nasal swabs‡ | BAL§ |
Urine | Stool | Cultured cells | Fresh-frozen tissue | FFPET* | ||
200 μL | ●1 | Up to 5 mg |
50 or 100 μL |
||||||||
200 μL | ●1 | 50 or 100 μL |
|||||||||
hgDNA ds 200 Protocol optimized for NGS |
200 μL |
●1 | 50 or 100 μL |
||||||||
500 or 1000 μL |
●2 | 100 or 200 μL |
|||||||||
6mm3 | 50 or 100 μL |
||||||||||
‡Nasal swabs=Nasopharyngeal/nasal swabs |
●1 Up to 5x105 cultured cells ●2 Up to 1x106 cultured cells |
Target: Cell-free NA | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Protocol name | Input sample type and sample volumes | Elution volume | ||||||||
Whole blood | Plasma | Serum | Nasal swabs‡ | BAL§ |
Urine | Stool | Cultured cells | Fresh-frozen tissue | ||
2000 μL | 50 or 100 μL | |||||||||
4000 μL | 50 or 100 μL | |||||||||
2000 μL | 100, 150 or 200 μL | |||||||||
4000 μL | 100, 150 or 200 μL | |||||||||
cfNA ds 4000 hp |
4000 μL |
60 or 150 μL | ||||||||
‡Nasal swabs=Nasopharyngeal/nasal swabs §BAL=Bronchoalveolar Lavage |
Target: Post elution | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Protocol name | Input sample type and sample volumes | Elution volume | ||||||||
Whole blood | Plasma | Serum | Nasal swabs‡ | BAL§ |
Urine | Stool | Cultured cells | Fresh-frozen tissue | ||
200, 500 or 1000 μL |
200, 500 or 1000 μL |
200, 500 or 1000 μL |
200, 500 or 1000 μL |
200, 500 or 1000 μL |
200, 500 or 1000 μL |
200, 500 or 1000 μL |
200, 500 or 1000 μL |
|||
Archiving for 25-50 μL per eluate FrameStrip low profile strips, or LightCycler® 8-tube strips |
||||||||||
‡Nasal swabs=Nasopharyngeal/nasal swabs §BAL=Bronchoalveolar Lavage |
Magnetism is used for automated nucleic acid isolation performed by the MagNA Pure 24 System. Magnetic glass particles (MGPs) are used to isolate RNA, DNA and total nucleic acids (tNA) from a variety of different sample materials.
Table: Key specifications of the MagNA Pure 24 System:
Sample Number: |
1 to 24 isolations per run |
Sample Volume: |
input of 200 µL to 4 mL |
Ability to mix batch within one run: |
yes |
Validated human sample types: |
whole blood, plasma, serum, nasal swab, BAL, urine, stool, cultured cells, fresh-frozen tissue, FFPET |
Run time for 24 isolations: |
Please refer to the MagNA Pure 24 protocol data sheet for more detail |
Reagent type: |
universal, prefilled, ready-to-use cassettes |
LIMS connectivity: |
yes |
21CFR part 11 (subsection B) compatibility: |
yes |
Labeling: |
CE-IVD (EU), IVD (US) |
The Magna Pure 24 system is on software version 1.1 currently.
View the archived database with the Archive Viewer.
If you need assistance to update your system software, please contact your local Roche representative.