Rabbit Anti-Human Aurora Kinase A/B/C Monoclonal Antibody (Clone SP201)

For research use only. Not for use in diagnostics.

Product No.	Pack Size
07068654001	0.1 mL

Product No.	Pack Size
07068689001	1.0 mL

To order these products, please contact your Roche order management team.

Keywords: Antibodies, Rabbit Monoclonal

Aurora kinases are highly conserved serine/threonine kinases in eukaryotes, involved in many processes during cell division. Three aurora kinases have been identified in humans and designated as Aurora-A, -B, and -C. They mostly consist of two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus. Aurora A regulates centrosome function during M phase and is required for initial activation of CDK1 at centrosomes and phosphorylates numerous target proteins. Over-expression of Aurora-A or -B protein can lead to aneuploid cells and is frequently observed in various human cancers such as prostate, breast, and esophageal cancers.

Figure above:
Human prostate cancer stained with anti-Aurora kinase A/B/C antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance


Human Prostate stained with anti-Aurora A/B/C antibody	Human Cervical SCCa stained with anti-Aurora A/B/C antibody	Human Colon stained with anti-Aurora A/B/C antibody	Human Testis stained with anti-Aurora A/B/C antibody

Human Uterus stained with anti-Aurora A/B/C antibody	Human Cervix stained with anti-Aurora A/B/C antibody	Human Tonsil stained with anti-Aurora A/B/C antibody	Human Placenta stained with anti-Aurora A/B/C antibody

Human Skin stained with anti-Aurora A/B/C antibody	Human Skin SCCa stained with anti-Aurora A/B/C antibody

Product Details:

Technology	Rabbit Monoclonal
Clone Name	SP201
Application	IHC-P, FACS
Species Reactivity
Tested	Hu
Predicted by homology	Bv, Fg, Pg, Rt
Isotype	Rabbit IgG
Immunogen	Synthetic peptide near the C-terminus of human Aurora kinase A, B, and C proteins.
Cellular Localization	Cytoplasm, Nucleus
Control Tissue	Human Prostate Carcinoma
Regulatory Rating	Research Use Only (RUO)
Entrez	6790
Storage Requirement	2-8°C
Target Molecular Weight	48 kDa (A), 40kDa (B), 35kDa (C)
Formulation	Refer to Data Sheet

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