Rabbit Anti-Human Aurora Kinase A/B/C Monoclonal Antibody (Clone SP201)
For research use only. Not for use in diagnostics.
Product No. | Pack Size |
---|---|
07068654001 | 0.1 mL |
Product No. | Pack Size |
---|---|
07068689001 | 1.0 mL |
To order these products, please contact your Roche order management team.
Aurora kinases are highly conserved serine/threonine kinases in eukaryotes, involved in many processes during cell division. Three aurora kinases have been identified in humans and designated as Aurora-A, -B, and -C. They mostly consist of two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus. Aurora A regulates centrosome function during M phase and is required for initial activation of CDK1 at centrosomes and phosphorylates numerous target proteins. Over-expression of Aurora-A or -B protein can lead to aneuploid cells and is frequently observed in various human cancers such as prostate, breast, and esophageal cancers.
Figure above:
Human prostate cancer stained with anti-Aurora kinase A/B/C antibody
Contents
Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
IHC Performance
Human Prostate stained with anti-Aurora A/B/C antibody |
Human Cervical SCCa stained with anti-Aurora A/B/C antibody |
Human Colon stained with anti-Aurora A/B/C antibody |
Human Testis stained with anti-Aurora A/B/C antibody |
Human Uterus stained with anti-Aurora A/B/C antibody |
Human Cervix stained with anti-Aurora A/B/C antibody |
Human Tonsil stained with anti-Aurora A/B/C antibody |
Human Placenta stained with anti-Aurora A/B/C antibody |
Human Skin stained with anti-Aurora A/B/C antibody |
Human Skin SCCa stained with anti-Aurora A/B/C antibody |
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP201 |
Application |
IHC-P, FACS |
Species Reactivity |
|
Tested |
Hu |
Predicted by homology |
Bv, Fg, Pg, Rt |
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide near the C-terminus of human Aurora kinase A, B, and C proteins. |
Cellular Localization |
Cytoplasm, Nucleus |
Control Tissue |
Human Prostate Carcinoma |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
6790 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
48 kDa (A), 40kDa (B), 35kDa (C) |
Formulation |
Refer to Data Sheet |