LifeScience
Rabbit Anti-Human Aurora Kinase A/B/C Monoclonal Antibody (Clone SP201)

Rabbit Anti-Human Aurora Kinase A/B/C Monoclonal Antibody (Clone SP201)

For research use only. Not for use in diagnostics.

Product No. Pack Size
07068654001 0.1 mL
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Product No. Pack Size
07068689001 1.0 mL

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Keywords: Rabbit Monoclonal

Aurora kinases are highly conserved serine/threonine kinases in eukaryotes, involved in many processes during cell division. Three aurora kinases have been identified in humans and designated as Aurora-A, -B, and -C. They mostly consist of two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus. Aurora A regulates centrosome function during M phase and is required for initial activation of CDK1 at centrosomes and phosphorylates numerous target proteins. Over-expression of Aurora-A or -B protein can lead to aneuploid cells and is frequently observed in various human cancers such as prostate, breast, and esophageal cancers.

Figure above:
Human prostate cancer stained with anti-Aurora kinase A/B/C antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human Prostate stained with anti-Aurora A/B/C antibody

Human Cervical SCCa stained with anti-Aurora A/B/C antibody

Human Colon stained with anti-Aurora A/B/C antibody

Human Testis stained with anti-Aurora A/B/C antibody

Human Uterus stained with anti-Aurora A/B/C antibody

Human Cervix stained with anti-Aurora A/B/C antibody

Human Tonsil stained with anti-Aurora A/B/C antibody

Human Placenta stained with anti-Aurora A/B/C antibody

Human Skin stained with anti-Aurora A/B/C antibody

Human Skin SCCa stained with anti-Aurora A/B/C antibody

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP201

Application

IHC-P, FACS

Species Reactivity

  

   Tested

Hu

   Predicted by homology

Bv, Fg, Pg, Rt

Isotype

Rabbit IgG

Immunogen

Synthetic peptide near the C-terminus of human Aurora kinase A, B, and C proteins.

Cellular Localization

Cytoplasm, Nucleus

Control Tissue

Human Prostate Carcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

6790

Storage Requirement

2-8°C

Target Molecular Weight

48 kDa (A), 40kDa (B), 35kDa (C)

Formulation

Refer to Data Sheet