Rabbit Anti-Human Cadherin-N/N-Cadherin Monoclonal Antibody (Clone SP90)
For research use only. Not for use in diagnostics.
Product No. | Pack Size |
---|---|
06972349001 | 0.1 mL |
Product No. | Pack Size |
---|---|
06972373001 | 1.0 mL |
To order these products, please contact your Roche order management team.
N-cadherin is a 140kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. The function of N-cadherin is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of β-catenin. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. **Please contact us for availability**
Figure above:
Human Mesothelioma stained with anti-Cadherin-N/N-Cadherin antibody
Contents
Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
IHC Performance
Human Mesothelioma stained with anti-Cadherin-N/N-Cadherin antibody |
Human Mesothelioma stained with anti-N-Cadherin antibody |
Human Liver stained with anti-N-Cadherin antibody |
Human Adrenal Gland stained with anti-N-Cadherin antibody |
Human Fallopian Tubes stained with anti-N-Cadherin antibody |
Human Renal Cell Carcinoma stained with anti-N-Cadherin antibody |
Human Stomach stained with anti-N-Cadherin antibody |
Flow Cytometric Analysis
Flow cytometric analysis of rabbit anti-Cadherin-N (SP90) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP90 |
Application |
IHC-P, FACS |
Species Reactivity |
|
Tested |
Hu |
Predicted by homology |
Bv, Ms, Rt |
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide corresponding to C-terminus of human cadherin-N protein. |
Cellular Localization |
Membrane |
Control Tissue |
Mesothelioma |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
1000 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
140 kDa |
Formulation |
Refer to Data Sheet |