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Rabbit Anti-Human Cadherin-N/N-Cadherin Monoclonal Antibody (Clone SP90)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06972349001 0.1 mL
Product No. Pack Size
06972373001 1.0 mL

To order these products, please contact your Roche order management team.

N-cadherin is a 140kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. The function of N-cadherin is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of β-catenin. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. **Please contact us for availability**

Figure above:
Human Mesothelioma stained with anti-Cadherin-N/N-Cadherin antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human Mesothelioma stained with anti-N-Cadherin antibody

Human Liver stained with anti-N-Cadherin antibody

Human Adrenal Gland stained with anti-N-Cadherin antibody

Human Mesothelioma stained with anti-Cadherin-N/N-Cadherin antibody

Human Mesothelioma stained with anti-N-Cadherin antibody

Human Liver stained with anti-N-Cadherin antibody

Human Adrenal Gland stained with anti-N-Cadherin antibody

Human Fallopian Tubes stained with anti-N-Cadherin antibody

Human Renal Cell Carcinoma stained with anti-N-Cadherin antibody

Human Stomach stained with anti-N-Cadherin antibody

Human Fallopian Tubes stained with anti-N-Cadherin antibody

Human Renal Cell Carcinoma stained with anti-N-Cadherin antibody

Human Stomach stained with anti-N-Cadherin antibody



Flow Cytometric Analysis

 

Flow cytometric analysis of rabbit anti-Cadherin-N (SP90) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)
Flow cytometric analysis of rabbit anti-Cadherin-N (SP90) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP90

Application

IHC-P, FACS

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Bv, Ms, Rt

Isotype

Rabbit IgG

Immunogen

Synthetic peptide corresponding to C-terminus of human cadherin-N protein.

Cellular Localization

Membrane

Control Tissue

Mesothelioma

Regulatory Rating

Research Use Only (RUO)

Entrez

1000

Storage Requirement

2-8°C

Target Molecular Weight

140 kDa

Formulation

Refer to Data Sheet