Rabbit Anti-Human ERCC1 Monoclonal Antibody (Clone SP68)

For research use only. Not for use in diagnostics.

Product No.	Pack Size
06971474001	0.1 mL

Product No.	Pack Size
06971512001	1.0 mL

To order these products, please contact your Roche order management team.

Keywords: Antibodies, Rabbit Monoclonal

The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision.

Figure above:
Human Lung Carcinoma stained with anti-ERCC1 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance


Human Lung Carcinoma stained with anti-ERCC1 antibody	Human Bladder Transitional Cell Carcinoma stained with anti-ERCC1 antibody	Human Breast Ductal Carcinoma stained with anti-ERCC1 antibody	Human Colon Adenocarcinoma stained with anti-ERCC1 antibody

Human Colon stained with anti-ERCC1 antibody	Human Hepatocellular Carcinoma stained with anti-ERCC1 antibody	Human Lung Adenocarcinoma stained with anti-ERCC1 antibody	Human Prostate Adenocarcinoma stained with anti-ERCC1 antibody

Human Renal Cell Carcinoma stained with anti-ERCC1 antibody	Human Skin Squamous Cell Carcinoma stained with anti-ERCC1 antibody	Human Testis stained with anti-ERCC1 antibody

Product Details:

Technology	Rabbit Monoclonal
Clone Name	SP68
Application	IHC-P
Species Reactivity
Tested	Hu
Predicted by homology	Bv, Hm, Ms, Pg, Rt
Isotype	Rabbit IgG
Immunogen	Recombinant human ERCC1 protein.
Cellular Localization	Nucleus
Control Tissue	Colon, Non-Small Cell Lung Carcinoma
Regulatory Rating	Research Use Only (RUO)
Entrez	2067
Storage Requirement	2-8°C
Target Molecular Weight	33-36 kDa
Formulation	Refer to Data Sheet

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