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Rabbit Anti-Human ERCC1 Monoclonal Antibody (Clone SP68)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06971474001 0.1 mL
Product No. Pack Size
06971512001 1.0 mL

To order these products, please contact your Roche order management team.

The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision.

Figure above:
Human Lung Carcinoma stained with anti-ERCC1 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human Lung Carcinoma stained with anti-ERCC1 antibody

Human Bladder Transitional Cell Carcinoma stained with anti-ERCC1 antibody

Human Breast Ductal Carcinoma stained with anti-ERCC1 antibody

Human Colon Adenocarcinoma stained with anti-ERCC1 antibody

Human Lung Carcinoma stained with anti-ERCC1 antibody

Human Bladder Transitional Cell Carcinoma stained with anti-ERCC1 antibody

Human Breast Ductal Carcinoma stained with anti-ERCC1 antibody

Human Colon Adenocarcinoma stained with anti-ERCC1 antibody

Human Colon stained with anti-ERCC1 antibody

Human Hepatocellular Carcinoma stained with anti-ERCC1 antibody

Human Lung Adenocarcinoma stained with anti-ERCC1 antibody

Human Prostate Adenocarcinoma stained with anti-ERCC1 antibody

Human Colon stained with anti-ERCC1 antibody

Human Hepatocellular Carcinoma stained with anti-ERCC1 antibody

Human Lung Adenocarcinoma stained with anti-ERCC1 antibody

Human Prostate Adenocarcinoma stained with anti-ERCC1 antibody

Human Renal Cell Carcinoma stained with anti-ERCC1 antibody

Human Skin Squamous Cell Carcinoma stained with anti-ERCC1 antibody

Human Testis stained with anti-ERCC1 antibody

Human Renal Cell Carcinoma stained with anti-ERCC1 antibody

Human Skin Squamous Cell Carcinoma stained with anti-ERCC1 antibody

Human Testis stained with anti-ERCC1 antibody

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP68

Application

IHC-P

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Bv, Hm, Ms, Pg, Rt

Isotype

Rabbit IgG

Immunogen

Recombinant human ERCC1 protein.

Cellular Localization

Nucleus

Control Tissue

Colon, Non-Small Cell Lung Carcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

2067

Storage Requirement

2-8°C

Target Molecular Weight

33-36 kDa

Formulation

Refer to Data Sheet