Rabbit Anti-Human FBXW7 Monoclonal Antibody (Clone SP237)
For research use only. Not for use in diagnostics.
| Product No. | Pack Size |
|---|---|
| 07133162001 | 0.1 mL |
| Product No. | Pack Size |
|---|---|
| 07135416001 | 1.0 mL |
To order these products, please contact your Roche order management team.
F-box/WD repeat-containing protein 7 (Fbxw7) is part of an ubiquitin-protein ligase complex. The complex ubiquitinates and degrades several important oncogenes such as mTOR, MYC, AURKA, JUN, and NOTCH1. Fbxw7 cooperates with PTEN for tumor suppression and is widely expressed in many normal tissues. The loss of fbxw7 is associated with malignant progression in a variety of tumors, including carcinoma of colorectum, lung, stomach, bile duct, endometrium, pancreas, breast and glioblastoma.
Figure above:
Human endometrial adenocarcinoma stained with anti-FBXW7 antibody
Contents
Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
IHC Performance
|
Human Endometrial adenocarcinoma stained with anti-FBXW7 antibody |
Flow Cytometric Analysis
|
Flow cytometric analysis of rabbit anti-FBXW7 (SP237) antibody in HL-60 (green) compare to negative control of rabbit IgG (blue) |
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP237 |
Application |
IHC-P, FACS |
Species Reactivity |
|
Tested |
Hu |
Predicted by homology |
Ms, Rt |
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide derived from the internal region of human FBXW7 protein. |
Cellular Localization |
Cytoplasm, Nucleus |
Control Tissue |
Endometrial Adenocarcinoma, Lung Squamous Cell Carcinoma |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
55294 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
80 kDa |
Formulation |
Refer to Data Sheet |
Instructions for Use (IFU)
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