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Rabbit Anti-Human FBXW7 Monoclonal Antibody (Clone SP237)

For research use only. Not for use in diagnostics.

Product No. Pack Size
07133162001 0.1 mL
Product No. Pack Size
07135416001 1.0 mL

To order these products, please contact your Roche order management team.

F-box/WD repeat-containing protein 7 (Fbxw7) is part of an ubiquitin-protein ligase complex. The complex ubiquitinates and degrades several important oncogenes such as mTOR, MYC, AURKA, JUN, and NOTCH1. Fbxw7 cooperates with PTEN for tumor suppression and is widely expressed in many normal tissues. The loss of fbxw7 is associated with malignant progression in a variety of tumors, including carcinoma of colorectum, lung, stomach, bile duct, endometrium, pancreas, breast and glioblastoma.

 

Figure above:
Human endometrial adenocarcinoma stained with anti-FBXW7 antibody

 

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human Endometrial adenocarcinoma stained with anti-FBXW7 antibody

Human Endometrial adenocarcinoma stained with anti-FBXW7 antibody



Flow Cytometric Analysis

 

Flow cytometric analysis of rabbit anti-FBXW7 (SP237) antibody in HL-60 (green) compare to negative control of rabbit IgG (blue)

Flow cytometric analysis of rabbit anti-FBXW7 (SP237) antibody in HL-60 (green) compare to negative control of rabbit IgG (blue)

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP237

Application

IHC-P, FACS

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Ms, Rt

Isotype

Rabbit IgG

Immunogen

Synthetic peptide derived from the internal region of human FBXW7 protein.

Cellular Localization

Cytoplasm, Nucleus

Control Tissue

Endometrial Adenocarcinoma, Lung Squamous Cell Carcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

55294

Storage Requirement

2-8°C

Target Molecular Weight

80 kDa

Formulation

Refer to Data Sheet