Rabbit Anti-Human Ku80 Monoclonal Antibody (Clone SP130)
For research use only. Not for use in diagnostics.
Product No. | Pack Size |
---|---|
06973841001 | 0.1 mL |
Product No. | Pack Size |
---|---|
06973876001 | 1.0 mL |
To order these products, please contact your Roche order management team.
X-ray repair cross-complementing protein 5 (XRCC5), alternative name (Ku80), is single stranded DNA-dependent ATP-dependent helicase. It involves in chromosome translocation. Ku80 along with Ku70 forms a heterodimeric protein originally identified as autoantigens associated with several autoimmune diseases including scleroderma, polymyositis and systemic lupus erythematosus. Ku is widely expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks. The inhibition of Ku80 can damage the DNA repair pathway of tumor cells and potentially increase the killing of cancer cells, and reduce drug resistance.
Figure above:
Human tonsil stained with anti-Ku80 antibody
Contents
Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
IHC Performance
Human Tonsil stained with anti-Ku80 antibody |
Western Blot Analysis
Western Blot analysis of HeLa cell lysate with Ku80 antibody
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP130 |
Application |
IHC-P, WB |
Species Reactivity |
|
Tested |
Hu |
Predicted by homology |
Rt, Bv |
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide corresponding to an internal region of human Ku80 protein. |
Cellular Localization |
Nucleus |
Control Tissue |
Tonsil |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
7520 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
86 kDa |
Formulation |
Refer to Data Sheet |