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Rabbit Anti-Human Ku80 Monoclonal Antibody (Clone SP130)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06973841001 0.1 mL
Product No. Pack Size
06973876001 1.0 mL

To order these products, please contact your Roche order management team.

X-ray repair cross-complementing protein 5 (XRCC5), alternative name (Ku80), is single stranded DNA-dependent ATP-dependent helicase. It involves in chromosome translocation. Ku80 along with Ku70 forms a heterodimeric protein originally identified as autoantigens associated with several autoimmune diseases including scleroderma, polymyositis and systemic lupus erythematosus. Ku is widely expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks. The inhibition of Ku80 can damage the DNA repair pathway of tumor cells and potentially increase the killing of cancer cells, and reduce drug resistance.

Figure above:
Human tonsil stained with anti-Ku80 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human Tonsil stained with anti-Ku80 antibody

Human Tonsil stained with anti-Ku80 antibody



Western Blot Analysis

 

Western Blot analysis of HeLa cell lysate with Ku80 antibody

Western Blot analysis of HeLa cell lysate with Ku80 antibody

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP130

Application

IHC-P, WB

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Rt, Bv

Isotype

Rabbit IgG

Immunogen

Synthetic peptide corresponding to an internal region of human Ku80 protein.

Cellular Localization

Nucleus

Control Tissue

Tonsil

Regulatory Rating

Research Use Only (RUO)

Entrez

7520

Storage Requirement

2-8°C

Target Molecular Weight

86 kDa

Formulation

Refer to Data Sheet