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Rabbit Anti-Human Lambda Light Chain Monoclonal Antibody (Clone SP147)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06974406001 0.1 mL
Product No. Pack Size
06974449001 1.0 mL

To order these products, please contact your Roche order management team.

Lambda light chains are polypeptide chains located in the cell membrane and cytoplasmic regions of normal B cells and plasma cells. The combination of lambda light chains and heavy chains forms immunoglobulin molecules. There are two classes of light chains found in immunoglobulins, kappa light chains and lambda light chains. Light chain production by lymphoid cells is genetically restricted such that the immunoglobulin molecules produced by an individual cell will only contain a single light chain class. This clonal restriction may be used to indicate the polyclonal or monoclonal nature of B cell and plasma cell populations. The ratio of Kappa to Lambda is about 2:1. The level of kappa or lambda can be greatly elevated in multiple myeloma or other B cell malignancies. **Please contact us for availability**

Figure above:
Human tonsil stained with anti-lambda light chain antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human B-Cell Lymphoma stained with anti-Lambda Light Chain antibody

Human Follicule Lymphoma stained with anti-Lambda Light Chain antibody

Human Thyroid stained with anti-Lambda Light Chain antibody

Human Tonsil stained with anti-lambda light chain antibody

Human B-Cell Lymphoma stained with anti-Lambda Light Chain antibody

Human Follicule Lymphoma stained with anti-Lambda Light Chain antibody

Human Thyroid stained with anti-Lambda Light Chain antibody

Human Tonsil stained with anti-lambda light chain antibody



Western Blot Analysis

 

Western Blot analysis of human spleen lysate with lambda light chain antibodyt

Western Blot analysis of human spleen lysate with lambda light chain antibody

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP147

Application

IHC-P, WB

Species Reactivity

 

   Tested

Hu

   Predicted by homology

N/A

Isotype

Rabbit IgG

Immunogen

Free lambda light chain from pooled human IgG lambda myeloma sera.

Cellular Localization

Cytoplasm

Control Tissue

Tonsil

Regulatory Rating

Research Use Only (RUO)

Entrez

N/A

Storage Requirement

2-8°C

Target Molecular Weight

25 kDa

Formulation

Refer to Data Sheet