Rabbit Anti-Human MSH2 Monoclonal Antibody (Clone SP46)

For research use only. Not for use in diagnostics.

Product No.	Pack Size
05497035001	0.1 mL

Product No.	Pack Size
05497051001	1.0 mL

To order these products, please contact your Roche order management team.

Keywords: Antibodies, Rabbit Monoclonal

MSH2 is involved in DNA repair as a mismatch repair protein, and mutations of MSH2 are found in approximately 50% of inherited non polyposis colorectal carcinoma (HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world.

Figure above:
Human Colon Carcinoma stained with anti-MSH2 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance


Human Colon Carcinoma stained with anti-MSH2 antibody	Human Tonsil stained with anti-MSH2 antibody	Human Thyroid stained with anti-MSH2 antibody	Human Skin stained with anti-MSH2 antibody

Human Prostate stained with anti-MSH2 antibody	Human Placenta stained with anti-MSH2 antibody	Human Lung stained with anti-MSH2 antibody	Human Endometrium stained with anti-MSH2 antibody

Human Colon stained with anti-MSH2 antibody	Human Colon Adenocarcinoma stained with anti-MSH2 antibody	Human Cervix stained with anti-MSH2 antibody

Flow Cytometric Analysis

Flow cytometric analysis of rabbit anti-MSH2 (SP46) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)

Product Details:

Technology	Rabbit Monoclonal
Clone Name	SP46
Application	IHC-P, FACS
Species Reactivity
Tested	Hu
Predicted by homology	Bv, Ck, Dg, Ms, Pg, Rt
Isotype	Rabbit IgG
Immunogen	Synthetic peptide corresponding to internal region of human MSH2.
Cellular Localization	Nucleus
Control Tissue	Colon Carcinoma
Regulatory Rating	Research Use Only (RUO)
Entrez	4436
Storage Requirement	2-8°C
Target Molecular Weight	100 kDa (Predicted)
Formulation	Refer to Data Sheet

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Rabbit Anti-Human MSH2 Monoclonal Antibody (Clone SP46)

Associated Products