Rabbit Anti-Human MSH2 Monoclonal Antibody (Clone SP46)
For research use only. Not for use in diagnostics.
Product No. | Pack Size |
---|---|
05497035001 | 0.1 mL |
Product No. | Pack Size |
---|---|
05497051001 | 1.0 mL |
To order these products, please contact your Roche order management team.
MSH2 is involved in DNA repair as a mismatch repair protein, and mutations of MSH2 are found in approximately 50% of inherited non polyposis colorectal carcinoma (HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world.
Figure above:
Human Colon Carcinoma stained with anti-MSH2 antibody
Contents
Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
IHC Performance
Human Colon Carcinoma stained with anti-MSH2 antibody |
Human Tonsil stained with anti-MSH2 antibody |
Human Thyroid stained with anti-MSH2 antibody |
Human Skin stained with anti-MSH2 antibody |
Human Prostate stained with anti-MSH2 antibody |
Human Placenta stained with anti-MSH2 antibody |
Human Lung stained with anti-MSH2 antibody |
Human Endometrium stained with anti-MSH2 antibody |
Human Colon stained with anti-MSH2 antibody |
Human Colon Adenocarcinoma stained with anti-MSH2 antibody |
Human Cervix stained with anti-MSH2 antibody |
Flow Cytometric Analysis
Flow cytometric analysis of rabbit anti-MSH2 (SP46) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP46 |
Application |
IHC-P, FACS |
Species Reactivity |
|
Tested |
Hu |
Predicted by homology |
Bv, Ck, Dg, Ms, Pg, Rt |
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide corresponding to internal region of human MSH2. |
Cellular Localization |
Nucleus |
Control Tissue |
Colon Carcinoma |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
4436 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
100 kDa (Predicted) |
Formulation |
Refer to Data Sheet |