Rabbit Anti-Human MSH6 Monoclonal Antibody (Clone SP93)

For research use only. Not for use in diagnostics.

Product No.	Pack Size
06972462001	0.1 mL

Product No.	Pack Size
06972519001	1.0 mL

To order these products, please contact your Roche order management team.

Keywords: Antibodies, Rabbit Monoclonal

Defects in MSH6 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world. MSH6 is central to mismatch DNA repair.

Figure above:
Human Rectal Carcinoma stained with anti-MSH6 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance


Human Rectal Carcinoma stained with anti-MSH6 antibody	Human Stomach stained with anti-MSH6 antibody	Human Bladder Transitional Cell Carcinoma stained with anti-MSH6 antibody	Human Stomach Adenocarcinoma stained with anti-MSH6 antibody

Human Small Intestine stained with anti-MSH6 antibody	Human Colon stained with anti-MSH6 antibody	Human Colon Adenocarcinoma stained with anti-MSH6 antibody	Human Lung Squamous Cell Carcinoma stained with anti-MSH6 antibody

Human Ovary stained with anti-MSH6 antibody	Human Ovarian Adenocarcinoma stained with anti-MSH6 antibody	Human Bladder stained with anti-MSH6 antibody

Western Blot Analysis

Western Blot of anti-MSH6 antibody

Product Details:

Technology	Rabbit Monoclonal
Clone Name	SP46
Application	IHC-P, FACS
Species Reactivity
Tested	Hu
Predicted by homology	Bv, Ck, Dg, Ms, Pg, Rt
Isotype	Rabbit IgG
Immunogen	Synthetic peptide corresponding to internal region of human MSH2.
Cellular Localization	Nucleus
Control Tissue	Colon Carcinoma
Regulatory Rating	Research Use Only (RUO)
Entrez	4436
Storage Requirement	2-8°C
Target Molecular Weight	100 kDa (Predicted)
Formulation	Refer to Data Sheet

Associated Products

Rabbit Anti-Human MSH2 Monoclonal Antibody (Clone SP46) Read more

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