Rabbit Anti-Human MSH6 Monoclonal Antibody (Clone SP93)
For research use only. Not for use in diagnostics.
| Product No. | Pack Size |
|---|---|
| 06972462001 | 0.1 mL |
| Product No. | Pack Size |
|---|---|
| 06972519001 | 1.0 mL |
To order these products, please contact your Roche order management team.
Defects in MSH6 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world. MSH6 is central to mismatch DNA repair.
Figure above:
Human Rectal Carcinoma stained with anti-MSH6 antibody
Contents
Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
IHC Performance
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Human Rectal Carcinoma stained with anti-MSH6 antibody |
Human Stomach stained with anti-MSH6 antibody |
Human Bladder Transitional Cell Carcinoma stained with anti-MSH6 antibody |
Human Stomach Adenocarcinoma stained with anti-MSH6 antibody |
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Human Small Intestine stained with anti-MSH6 antibody |
Human Colon stained with anti-MSH6 antibody |
Human Colon Adenocarcinoma stained with anti-MSH6 antibody |
Human Lung Squamous Cell Carcinoma stained with anti-MSH6 antibody |
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Human Ovary stained with anti-MSH6 antibody |
Human Ovarian Adenocarcinoma stained with anti-MSH6 antibody |
Human Bladder stained with anti-MSH6 antibody |
Western Blot Analysis
Western Blot of anti-MSH6 antibody
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP46 |
Application |
IHC-P, FACS |
Species Reactivity |
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Tested |
Hu |
Predicted by homology |
Bv, Ck, Dg, Ms, Pg, Rt |
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide corresponding to internal region of human MSH2. |
Cellular Localization |
Nucleus |
Control Tissue |
Colon Carcinoma |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
4436 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
100 kDa (Predicted) |
Formulation |
Refer to Data Sheet |
Associated Products
Instructions for Use (IFU)
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