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Rabbit Anti-Human MSH6 Monoclonal Antibody (Clone SP93)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06972462001 0.1 mL
Product No. Pack Size
06972519001 1.0 mL

To order these products, please contact your Roche order management team.

Defects in MSH6 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world. MSH6 is central to mismatch DNA repair.

Figure above:
Human Rectal Carcinoma stained with anti-MSH6 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human Rectal Carcinoma stained with anti-MSH6 antibody

Human Stomach stained with anti-MSH6 antibody

Human Bladder Transitional Cell Carcinoma stained with anti-MSH6 antibody

Human Stomach Adenocarcinoma stained with anti-MSH6 antibody

Human Rectal Carcinoma stained with anti-MSH6 antibody

Human Stomach stained with anti-MSH6 antibody

Human Bladder Transitional Cell Carcinoma stained with anti-MSH6 antibody

Human Stomach Adenocarcinoma stained with anti-MSH6 antibody

Human Small Intestine stained with anti-MSH6 antibody

Human Colon stained with anti-MSH6 antibody

Human Colon Adenocarcinoma stained with anti-MSH6 antibody

Human Lung Squamous Cell Carcinoma stained with anti-MSH6 antibody

Human Small Intestine stained with anti-MSH6 antibody

Human Colon stained with anti-MSH6 antibody

Human Colon Adenocarcinoma stained with anti-MSH6 antibody

Human Lung Squamous Cell Carcinoma stained with anti-MSH6 antibody

Human Ovary stained with anti-MSH6 antibody

Human Ovarian Adenocarcinoma stained with anti-MSH6 antibody

Human Bladder stained with anti-MSH6 antibody

Human Ovary stained with anti-MSH6 antibody

Human Ovarian Adenocarcinoma stained with anti-MSH6 antibody

Human Bladder stained with anti-MSH6 antibody



Western Blot Analysis

 

Western Blot of anti-MSH6 antibody
Western Blot of anti-MSH6 antibody

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP46

Application

IHC-P, FACS

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Bv, Ck, Dg, Ms, Pg, Rt

Isotype

Rabbit IgG

Immunogen

Synthetic peptide corresponding to internal region of human MSH2.

Cellular Localization

Nucleus

Control Tissue

Colon Carcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

4436

Storage Requirement

2-8°C

Target Molecular Weight

100 kDa (Predicted)

Formulation

Refer to Data Sheet