Welcome

You've successfully logged in

This website uses cookies to provide you with a more responsive and personalized service. In order to proceed to login, however, you must formally accept our cookie policy. Please read our cookie & privacy policies for more information.

Rabbit Anti-Human N-Ras (Q61R) Monoclonal Antibody (Clone SP174)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06771017001 0.1 mL
Product No. Pack Size
06771033001 1.0 mL

To order these products, please contact your Roche order management team.

GTPase N-Ras or N-Ras is a guanine-nucleotide binding protein. Receptor tyrosine kinases and G-protein-coupled receptors activate Ras, which then stimulates the MAPK signal pathway. Point mutations (Q61R) in Ras prevent the GAP-mediated inhibition of the MAPK pathway in certain cancers such as lung carcinoma and melanoma. Abnormal MAPK signaling may lead to uncontrolled cell proliferation, resistance to both apoptosis and cancer therapy. **Please contact us for availability**

Figure above:
SK-MEL-2 cells stained with anti-N-Ras (Q61R) antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

SK-MEL-2 cells stained with anti-N-Ras (Q61R) antibody

SK-MEL-2 cells stained with anti-N-Ras (Q61R) antibody



Western Blot Analysis

 

Western Blot analysis of SK-MEL-2 cell lysate with N-Ras (Q61R) antibody


Western Blot analysis of SK-MEL-2 cell lysate with N-Ras (Q61R) antibody

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP174

Application

IHC-P, WB

Species Reactivity

 

   Tested

Hu

   Predicted by homology

N/A

Isotype

Rabbit IgG

Immunogen

Synthetic peptide of human N-Ras protein containing N-Ras (Q61R) point mutation.

Cellular Localization

Membrane

Control Tissue

SK-MEL-2 Cell Line

Regulatory Rating

Research Use Only (RUO)

Entrez

4893

Storage Requirement

2-8°C

Target Molecular Weight

21 kDa

Formulation

Refer to Data Sheet