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Rabbit Anti-Human p53 Monoclonal Antibody (Clone SP161)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06974988001 0.1 mL
Product No. Pack Size
06975011001 1.0 mL

To order these products, please contact your Roche order management team.

p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein. p53 senses DNA damage and possibly facilitates repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Figure above:
Human Colon Adenocarcinoma stained with anti-p53 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human B-cell lymphoma stained with anti-P53 antibody

Human Bladder Transitional Cell Carcinoma stained with anti-P53 antibody

Human Breast Ductal Carcinoma stained with anti-P53 antibody

Human Colon Adenocarcinoma stained with anti-p53 antibody

Human B-cell lymphoma stained with anti-P53 antibody

Human Bladder Transitional Cell Carcinoma stained with anti-P53 antibody

Human Breast Ductal Carcinoma stained with anti-P53 antibody

Human Colon Adenocarcinoma stained with anti-p53 antibody

Human Lung Squamous Cell Carcinoma stained with anti-P53 antibody

Human Ovarian Adenocarcinoma stained with anti-P53 antibody

Human Stomach Adenocarcinoma stained with anti-P53 antibody

Human Lung Squamous Cell Carcinoma stained with anti-P53 antibody

Human Ovarian Adenocarcinoma stained with anti-P53 antibody

Human Stomach Adenocarcinoma stained with anti-P53 antibody

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP161

Application

IHC-P

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Bv, Dg, Hm, Ms, Pg, Rb, Rt

Isotype

Rabbit IgG

Immunogen

Recombinant human full length wild type p53 protein.

Cellular Localization

Nucleus

Control Tissue

Colon Carcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

7157

Storage Requirement

2-8°C

Target Molecular Weight

53 kDa

Formulation

Refer to Data Sheet