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Rabbit Anti-Human PD-1/CD279 Monoclonal Antibody (Clone SP269)

For research use only. Not for use in diagnostics.

Product No. Pack Size
07489161001 0.1 mL
Product No. Pack Size
07489218001 1.0 mL

To order these products, please contact your Roche order management team.

Programmed cell death protein 1 (PD-1), as known as CD279, is a member of CD28/CTLA-4 family of T cell regulators. It is expressed on the surface of activated T cells, B cells, and macrophages as a negative regulator for immune responses. The binding of PD-1 with its ligands PDL1 and PDL2 on T cells, monocytes, and some tumor cells can trigger inhibition of T-cell function.

Figure above:
Human tonsil stained with anti-PD-1 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human Tonsil stained with anti-PD-1 antibody

Human Tonsil stained with anti-PD-1 antibody



Flow Cytometric Analysis

 

Flow cytometric analysis of rabbit anti-PD-1 (SP269) antibody in THP- 1 cells (green) compare to negative control of rabbit IgG (blue)

Flow cytometric analysis of rabbit anti-PD-1 (SP269) antibody in THP- 1 cells (green) compare to negative control of rabbit IgG (blue)

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP269

Application

IHC-P, FACS

Species Reactivity

 

   Tested

Hu

   Predicted by homology

N/A

Isotype

Rabbit IgG

Immunogen

Synthetic peptide derived from the N-terminus of human PD-1 protein.

Cellular Localization

Membrane

Control Tissue

Tonsil

Regulatory Rating

Research Use Only (RUO)

Entrez

5133

Storage Requirement

2-8°C

Target Molecular Weight

32 kDa

Formulation

Refer to Data Sheet