Rabbit Anti-Human PD-L1/CD274 Monoclonal Antibody (Clone SP142)
For research use only. Not for use in diagnostics.
| Product No. | Pack Size |
|---|---|
| 07309457001 | 0.1 mL |
| Product No. | Pack Size |
|---|---|
| 07309554001 | 1.0 mL |
To order these products, please contact your Roche order management team.
Programmed cell death ligand 1 (PD-L1) also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1) is a type 1 transmembrane protein involved in the regulation of cellular and humoral immune responses. The interaction of PD-L1 with its receptor PD-1 provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is mainly expressed in antigen presenting cells, activated T and B cells, placenta, and some tumors such as melanoma, diffuse large B-cell lymphoma, and carcinoma of the lung, colon, and rectum.
Figure above:
Human placenta stained with anti-PD-L1 antibody
Contents
Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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Human lung squamous cell carcinoma stained with anti-PD-L1 antibody |
Human Hodgkin's lymphoma stained with anti-PD-L1 antibody |
Human placenta stained with anti-PD-L1 antibody |
Human tonsil stained with anti-PD-L1 antibody |
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Human cervical squamous cell carcinoma stained with anti-PD-L1 antibody |
Human pancreatic adenocarcinoma stained with anti-PD-L1 antibody |
Human skin squamous cell carcinoma stained with anti-PD-L1 antibody |
Human prostate adenocarcinoma stained with anti-PD-L1 antibody |
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP124 |
Application |
IHC-P, |
Species Reactivity |
|
Tested |
Hu |
Predicted by homology |
N/A |
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide derived from the C-terminus of human PD-L1 protein. |
Cellular Localization |
Membrane |
Control Tissue |
Placenta |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
29126 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
42 kDa |
Formulation |
Refer to Data Sheet |
Associated Products
Instructions for Use (IFU)
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