Rabbit Anti-Human PHLPP2 Monoclonal Antibody (Clone SP220)

PHLPP2 (PH domain and leucine-rich repeat protein phosphatases 2) is a membrane-bound protein with dual functions as a tumor suppressor and a protein phosphatase. It mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA as well as AKT3 phosphorylation. Dephosphorylation of AKT1, PRKCA and PRKCB leads to their destabilization and degradation and inhibits cancer cell proliferation.

Figure above:
Human prostate adenocarcinoma stained with anti-PHLPP2 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.