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Rabbit Anti-Human PHLPP2 Monoclonal Antibody (Clone SP220)

For research use only. Not for use in diagnostics.

Product No. Pack Size
07070195001 0.1 mL
Product No. Pack Size
07070217001 1.0 mL

To order these products, please contact your Roche order management team.

PHLPP2 (PH domain and leucine-rich repeat protein phosphatases 2) is a membrane-bound protein with dual functions as a tumor suppressor and a protein phosphatase. It mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA as well as AKT3 phosphorylation. Dephosphorylation of AKT1, PRKCA and PRKCB leads to their destabilization and degradation and inhibits cancer cell proliferation.

Figure above:
Human prostate adenocarcinoma stained with anti-PHLPP2 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human Normal Prostate stained with anti-PHLLP2 antibody

Human Prostate adenocarcinoma stained with anti-PHLPP2 antibody

Human Normal Prostate stained with anti-PHLLP2 antibody

Human Prostate adenocarcinoma stained with anti-PHLPP2 antibody



Western Blot Analysis


Western Blot analysis of HEK293T cell lysate with anti-PHLPP2 antibody

Western Blot analysis of HEK293T cell lysate with anti-PHLPP2 antibody

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP220

Application

IHC-P, WB

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Ms

Isotype

Rabbit IgG

Immunogen

Synthetic peptide derived from human PHLPP2 protein.

Cellular Localization

Cytoplasm, Membrane, Nucleus

Control Tissue

Prostate, Prostate Adenocarcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

23035

Storage Requirement

2-8°C

Target Molecular Weight

190 kDa

Formulation

Refer to Data Sheet