Rabbit Anti-Human PHLPP2 Monoclonal Antibody (Clone SP220)
For research use only. Not for use in diagnostics.
| Product No. | Pack Size |
|---|---|
| 07070195001 | 0.1 mL |
| Product No. | Pack Size |
|---|---|
| 07070217001 | 1.0 mL |
To order these products, please contact your Roche order management team.
PHLPP2 (PH domain and leucine-rich repeat protein phosphatases 2) is a membrane-bound protein with dual functions as a tumor suppressor and a protein phosphatase. It mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA as well as AKT3 phosphorylation. Dephosphorylation of AKT1, PRKCA and PRKCB leads to their destabilization and degradation and inhibits cancer cell proliferation.
Figure above:
Human prostate adenocarcinoma stained with anti-PHLPP2 antibody
Contents
Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
IHC Performance
|
|
Human Normal Prostate stained with anti-PHLLP2 antibody |
Human Prostate adenocarcinoma stained with anti-PHLPP2 antibody |
Western Blot Analysis
Western Blot analysis of HEK293T cell lysate with anti-PHLPP2 antibody
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP220 |
Application |
IHC-P, WB |
Species Reactivity |
|
Tested |
Hu |
Predicted by homology |
Ms |
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide derived from human PHLPP2 protein. |
Cellular Localization |
Cytoplasm, Membrane, Nucleus |
Control Tissue |
Prostate, Prostate Adenocarcinoma |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
23035 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
190 kDa |
Formulation |
Refer to Data Sheet |
Associated Products
Instructions for Use (IFU)
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