Rabbit Anti-Human PSMA Monoclonal Antibody (Clone SP29)
For research use only. Not for use in diagnostics.
Product No. | Pack Size |
---|---|
05498368001 | 0.1 mL |
Product No. | Pack Size |
---|---|
05298890001 | 1.0 mL |
To order these products, please contact your Roche order management team.
PMSA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region.
Figure above:
Human Prostate Carcinoma stained with anti-PSMA antibody
Contents
Rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.
IHC Performance
Human Prostate Carcinoma stained with anti-PSMA antibody |
Human Prostate Adenocarcinoma stained with anti-PSMA antibody |
Human Prostate Adenocarcinoma stained with anti-PSMA antibody |
Human Prostate Adenocarcinoma stained with anti-PSMA antibody |
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP29 |
Application |
IHC-P |
Species Reactivity |
|
Tested |
Hu |
Predicted by homology |
Bv, Dg, Ms, Pg, Rt |
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide derived from C-terminus of human PSMA. |
Cellular Localization |
Membrane |
Control Tissue |
Prostate Carcinoma |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
2346 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
84 kDa |
Formulation |
Refer to Data Sheet |