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Rabbit Anti-Human PTEN Monoclonal Antibody (Clone SP170)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06771050001 0.1 mL
Product No. Pack Size
06771076001 1.0 mL

To order these products, please contact your Roche order management team.

Phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (PTEN) is a tumor suppressor and a member in the PI3K/PTEN/AKT pathway. PTEN is a phosphatase with dual specificity to slow cell growth and antagonize the growth promoting activities from HER protein kinases. The defects of PTEN, mostly around the C-terminus of PTEN, have been implicated in many human cancers and diseases. Therefore, antibody to the N terminus will not be able to detect most of the PTEN protein loss. **Please contact us for availability**

Figure above:
Human prostate adenocarcinoma stained with anti-PTEN antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

Human Cervical Squamous Cell Carcinoma stained with anti-PTEN antibody

Human Colon Adenocarcinoma stained with anti-PTEN antibody

Human Lung Squamous Cell Carcinoma stained with anti-PTEN antibody

Human Ovarian Carcinoma stained with anti-PTEN antibody

Human Cervical Squamous Cell Carcinoma stained with anti-PTEN antibody

Human Colon Adenocarcinoma stained with anti-PTEN antibody

Human Lung Squamous Cell Carcinoma stained with anti-PTEN antibody

Human Ovarian Carcinoma stained with anti-PTEN antibody

Human Ovary stained with anti-PTEN antibody

Human Prostate Adencarcinoma stained with anti-PTEN antibody

Human Prostate Adencarcinoma stained with anti-PTEN antibody

Human Prostate  adenocarcinoma stained with anti-PTEN antibody

Human Ovary stained with anti-PTEN antibody

Human Prostate Adencarcinoma stained with anti-PTEN antibody

Human Prostate Adencarcinoma stained with anti-PTEN antibody

Human Prostate adenocarcinoma stained with anti-PTEN antibody

Human Prostate Adenocarcinoma stained with anti-PTEN antibody

Human Prostate stained with anti-PTEN antibody

Human Stomach Adenocarcinoma stained with anti-PTEN antibody

Human Prostate Adenocarcinoma stained with anti-PTEN antibody

Human Prostate stained with anti-PTEN antibody

Human Stomach Adenocarcinoma stained with anti-PTEN antibody



Flow Cytometric Analysis

 

Flow cytometric analysis of rabbit anti-PTEN (SP170) antibody in A431 (green) compare to negative control of rabbit IgG (blue)

Flow cytometric analysis of rabbit anti-PTEN (SP170) antibody in A431 (green) compare to negative control of rabbit IgG (blue)



Western Blot Analysis

 

Western Blot analysis of MCF-7 cell lysate with PTEN antibody

Western Blot analysis of MCF-7 cell lysate with PTEN antibody

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP170

Application

IHC-P, WB, FACS

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Dg, Ms

Isotype

Rabbit IgG

Immunogen

Synthetic peptide close to the N-terminus of human PTEN protein.

Cellular Localization

Cytoplasm

Control Tissue

Prostate Adenocarcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

5728

Storage Requirement

2-8°C

Target Molecular Weight

54 kDa

Formulation

Refer to Data Sheet