Rabbit Anti-Human PTEN Monoclonal Antibody (Clone SP170)

For research use only. Not for use in diagnostics.

Product No.	Pack Size
06771050001	0.1 mL

Product No.	Pack Size
06771076001	1.0 mL

To order these products, please contact your Roche order management team.

Keywords: Antibodies, Rabbit Monoclonal

Phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (PTEN) is a tumor suppressor and a member in the PI3K/PTEN/AKT pathway. PTEN is a phosphatase with dual specificity to slow cell growth and antagonize the growth promoting activities from HER protein kinases. The defects of PTEN, mostly around the C-terminus of PTEN, have been implicated in many human cancers and diseases. Therefore, antibody to the N terminus will not be able to detect most of the PTEN protein loss. **Please contact us for availability**

Figure above:
Human prostate adenocarcinoma stained with anti-PTEN antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance


Human Cervical Squamous Cell Carcinoma stained with anti-PTEN antibody	Human Colon Adenocarcinoma stained with anti-PTEN antibody	Human Lung Squamous Cell Carcinoma stained with anti-PTEN antibody	Human Ovarian Carcinoma stained with anti-PTEN antibody

Human Ovary stained with anti-PTEN antibody	Human Prostate Adencarcinoma stained with anti-PTEN antibody	Human Prostate Adencarcinoma stained with anti-PTEN antibody	Human Prostate adenocarcinoma stained with anti-PTEN antibody

Human Prostate Adenocarcinoma stained with anti-PTEN antibody	Human Prostate stained with anti-PTEN antibody	Human Stomach Adenocarcinoma stained with anti-PTEN antibody

Flow Cytometric Analysis

Flow cytometric analysis of rabbit anti-PTEN (SP170) antibody in A431 (green) compare to negative control of rabbit IgG (blue)

Western Blot Analysis

Western Blot analysis of MCF-7 cell lysate with PTEN antibody

Product Details:

Technology	Rabbit Monoclonal
Clone Name	SP170
Application	IHC-P, WB, FACS
Species Reactivity
Tested	Hu
Predicted by homology	Dg, Ms
Isotype	Rabbit IgG
Immunogen	Synthetic peptide close to the N-terminus of human PTEN protein.
Cellular Localization	Cytoplasm
Control Tissue	Prostate Adenocarcinoma
Regulatory Rating	Research Use Only (RUO)
Entrez	5728
Storage Requirement	2-8°C
Target Molecular Weight	54 kDa
Formulation	Refer to Data Sheet

Associated Products

Rabbit Anti-Human PTEN Monoclonal Antibody (Clone SP218) Read more

Rabbit Anti-Human Cleaved PTEN (D301) Monoclonal Antibody (Clone SP227) Read more

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