Rabbit Anti-Human RRM1 Monoclonal Antibody (Clone SP167)
For research use only. Not for use in diagnostics.
Product No. | Pack Size |
---|---|
06975232001 | 0.1 mL |
Product No. | Pack Size |
---|---|
06975224001 | 1.0 mL |
To order these products, please contact your Roche order management team.
Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.
Figure above:
Human Lung Adenocarcinoma stained with anti-RRM1 antibody
Contents
Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
IHC Performance
Human Bronchioloalveolar Carcinoma stained with anti-RRM-1 antibody |
Human Bronchus stained with anti-RRM-1 antibody |
Human Lung Adenocarcinoma stained with anti-RRM1 antibody |
Human Lung Adenocarcinoma stained with anti-RRM-1 antibody |
Human Lung Adenocarcinoma stained with anti-RRM-1 antibody |
Human Lung Adenosquamous Carcinoma stained with anti-RRM-1 antibody |
Human Lung Clear Cell Carcinoma stained with anti-RRM-1 antibody |
Human Lung Granuloma stained with anti-RRM-1 antibody |
Human Lung Papillary Adenocarcinoma stained with anti-RRM-1 antibody |
Human Lung Small Cell Carcinoma stained with anti-RRM-1 antibody |
Human Lung Squamous Cell Carcinoma stained with anti-RRM-1 antibody |
Human Lung Undifferentiated Large Cell Carcinoma stained with anti-RRM-1 antibody5 |
Flow Cytometric Analysis
Flow cytometric analysis of rabbit anti-RRM1 (SP167) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP167 |
Application |
IHC-P, FACS |
Species Reactivity |
|
Tested |
Hu |
Predicted by homology |
Bv, Ms |
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide in the internal region of human RRM1 protein. |
Cellular Localization |
Cytoplasm |
Control Tissue |
Lung Adenocarcinoma |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
6240 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
90 kDa |
Formulation |
Refer to Data Sheet |