LifeScience
Rabbit Anti-Human RRM1 Monoclonal Antibody (Clone SP167)

Rabbit Anti-Human RRM1 Monoclonal Antibody (Clone SP167)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06975232001 0.1 mL
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Product No. Pack Size
06975224001 1.0 mL

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Keywords: Antibodies, Rabbit Monoclonal

Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.

Figure above:
Human Lung Adenocarcinoma stained with anti-RRM1 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human Bronchioloalveolar Carcinoma stained with anti-RRM-1 antibody

Human Bronchus stained with anti-RRM-1 antibody

Human Lung Adenocarcinoma stained with anti-RRM1 antibody

Human Lung Adenocarcinoma stained with anti-RRM-1 antibody

Human Bronchioloalveolar Carcinoma stained with anti-RRM-1 antibody

Human Bronchus stained with anti-RRM-1 antibody

Human Lung Adenocarcinoma stained with anti-RRM1 antibody

Human Lung Adenocarcinoma stained with anti-RRM-1 antibody

Human Lung Adenocarcinoma stained with anti-RRM-1 antibody

Human Lung Adenosquamous Carcinoma stained with anti-RRM-1 antibody

Human Lung Clear Cell Carcinoma stained with anti-RRM-1 antibody

Human Lung Granuloma stained with anti-RRM-1 antibody

Human Lung Adenocarcinoma stained with anti-RRM-1 antibody

Human Lung Adenosquamous Carcinoma stained with anti-RRM-1 antibody

Human Lung Clear Cell Carcinoma stained with anti-RRM-1 antibody

Human Lung Granuloma stained with anti-RRM-1 antibody

Human Lung Papillary Adenocarcinoma stained with anti-RRM-1 antibody

Human Lung Small Cell Carcinoma stained with anti-RRM-1 antibody

Human Lung Squamous Cell Carcinoma stained with anti-RRM-1 antibody

Human Lung Undifferentiated Large Cell Carcinoma stained with anti-RRM-1 antibody5

Human Lung Papillary Adenocarcinoma stained with anti-RRM-1 antibody

Human Lung Small Cell Carcinoma stained with anti-RRM-1 antibody

Human Lung Squamous Cell Carcinoma stained with anti-RRM-1 antibody

Human Lung Undifferentiated Large Cell Carcinoma stained with anti-RRM-1 antibody5



Flow Cytometric Analysis

 

Flow cytometric analysis of rabbit anti-RRM1 (SP167) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)

Flow cytometric analysis of rabbit anti-RRM1 (SP167) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)


Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP167

Application

IHC-P, FACS

Species Reactivity

  

   Tested

Hu

   Predicted by homology

Bv, Ms

Isotype

Rabbit IgG

Immunogen

Synthetic peptide in the internal region of human RRM1 protein.

Cellular Localization

Cytoplasm

Control Tissue

Lung Adenocarcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

6240

Storage Requirement

2-8°C

Target Molecular Weight

90 kDa

Formulation

Refer to Data Sheet