Rabbit Anti-Human RRM1 Monoclonal Antibody (Clone SP167)

For research use only. Not for use in diagnostics.

Product No.	Pack Size
06975232001	0.1 mL

Product No.	Pack Size
06975224001	1.0 mL

To order these products, please contact your Roche order management team.

Keywords: Antibodies, Rabbit Monoclonal

Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.

Figure above:
Human Lung Adenocarcinoma stained with anti-RRM1 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance


Human Bronchioloalveolar Carcinoma stained with anti-RRM-1 antibody	Human Bronchus stained with anti-RRM-1 antibody	Human Lung Adenocarcinoma stained with anti-RRM1 antibody	Human Lung Adenocarcinoma stained with anti-RRM-1 antibody

Human Lung Adenocarcinoma stained with anti-RRM-1 antibody	Human Lung Adenosquamous Carcinoma stained with anti-RRM-1 antibody	Human Lung Clear Cell Carcinoma stained with anti-RRM-1 antibody	Human Lung Granuloma stained with anti-RRM-1 antibody

Human Lung Papillary Adenocarcinoma stained with anti-RRM-1 antibody	Human Lung Small Cell Carcinoma stained with anti-RRM-1 antibody	Human Lung Squamous Cell Carcinoma stained with anti-RRM-1 antibody	Human Lung Undifferentiated Large Cell Carcinoma stained with anti-RRM-1 antibody5

Flow Cytometric Analysis

Flow cytometric analysis of rabbit anti-RRM1 (SP167) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)

Product Details:

Technology	Rabbit Monoclonal
Clone Name	SP167
Application	IHC-P, FACS
Species Reactivity
Tested	Hu
Predicted by homology	Bv, Ms
Isotype	Rabbit IgG
Immunogen	Synthetic peptide in the internal region of human RRM1 protein.
Cellular Localization	Cytoplasm
Control Tissue	Lung Adenocarcinoma
Regulatory Rating	Research Use Only (RUO)
Entrez	6240
Storage Requirement	2-8°C
Target Molecular Weight	90 kDa
Formulation	Refer to Data Sheet

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