Rabbit Anti-Human Tau Monoclonal Antibody (Clone SP70)
For research use only. Not for use in diagnostics.
Product No. | Pack Size |
---|---|
06971571001 | 0.1 mL |
Product No. | Pack Size |
---|---|
06971601001 | 1.0 mL |
To order these products, please contact your Roche order management team.
Tau is a neuronal microtubule associated protein found predominantly on axons. The function of rau is to promote tubulin polymerization and stabilize microtubules, but it also serves to link certain signaling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate tau. Alternate splicing of tau mRNA and differential phosphorylation contributes to the heterogeneity of Tau. **Please contact us for availability**
Figure above:
Human Breast Carcinoma stained with anti-Tau (Neuronal Marker) antibody
Contents
Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
IHC Performance
Human Breast stained with anti-Tau antibody |
Human Breast Adenocarcinoma stained with anti-Tau antibody |
Human Prostate Adenocarcinoma stained with anti-Tau antibody |
Human Renal Cell Carcinoma stained with anti-Tau antibody |
Human Pancreas stained with anti-Tau antibody |
Human Colon stained with anti-Tau antibody |
Human Small Intestine stained with anti-Tau antibody |
Human Bladder stained with anti-Tau antibody |
Human Spinal Cord stained with anti-Tau antibody |
Human Cerebellum stained with anti-Tau antibody |
Human Cerebral Cortex stained with anti-Tau antibody |
Flow Cytometric Analysis
Flow cytometric analysis of rabbit anti-Tau (Neuronal Marker) (SP70) antibody in SH-SY5Y (green) compare to negative control of rabbit IgG (blue)
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP70 |
Application |
IHC-P, FACS |
Species Reactivity |
|
Tested |
Hu |
Predicted by homology |
|
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide corresponding to N-terminus of human tau protein. |
Cellular Localization |
Cytoplasm |
Control Tissue |
Breast Carcinoma |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
4137 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
45-68 kDa |
Formulation |
Refer to Data Sheet |