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LifeScience

Rabbit Anti-Human Thymidylate Synthase (TS) Monoclonal Antibody (Clone SP112)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06973183001 0.1 mL
Contact Us
Product No. Pack Size
06973213001 1.0 mL

To order these products, please contact your Roche order management team.

Keywords: Antibodies, Rabbit Monoclonal

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma. **Please contact us for availability**

Figure above:
Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody

Human Tonsil stained with anti-TS antibody

Human Colorectal Adenocarcinoma stained with anti-TS antibody

Human Bladder Transitional Cell Carcinoma stained with anti-TS antibody

Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody

Human Tonsil stained with anti-TS antibody

Human Colorectal Adenocarcinoma stained with anti-TS antibody

Human Bladder Transitional Cell Carcinoma stained with anti-TS antibody

Human Hepatocellular Carcinoma stained with anit-TS antibody

Human Lung SCCa stained with anti-TS antibody

Human Lymph Node stained with anti-TS antibody

Human B Cell Lymphoma stained with anti-TS antibody

Human Hepatocellular Carcinoma stained with anit-TS antibody

Human Lung SCCa stained with anti-TS antibody

Human Lymph Node stained with anti-TS antibody

Human B Cell Lymphoma stained with anti-TS antibody

Human Ovarian Adenocarcinoma stained with anti-TS antibody

Human Pancreatic Adenocarcinoma stained with anti-TS antibody

Human Stomach Adenocarcinoma stained with anti-TS antibody

Human Ovarian Adenocarcinoma stained with anti-TS antibody

Human Pancreatic Adenocarcinoma stained with anti-TS antibody

Human Stomach Adenocarcinoma stained with anti-TS antibody

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP112

Application

IHC-P

Species Reactivity

  

   Tested

Hu

   Predicted by homology

Bv, Fg, Ms, Rb, Rt

Isotype

Rabbit IgG

Immunogen

Synthetic peptide near C-terminus of human TS.

Cellular Localization

Cytoplasm, Nucleus

Control Tissue

Colon Carcinoma, Tonsil

Regulatory Rating

Research Use Only (RUO)

Entrez

7298

Storage Requirement

2-8°C

Target Molecular Weight

36 kDa

Formulation

Refer to Data Sheet