LifeScience

Rabbit Anti-Human Thymidylate Synthase (TS) Monoclonal Antibody (Clone SP112)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06973183001 0.1 mL
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Product No. Pack Size
06973213001 1.0 mL

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Keywords: Rabbit Monoclonal

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma. **Please contact us for availability**

Figure above:
Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance

 

Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody

Human Tonsil stained with anti-TS antibody

Human Colorectal Adenocarcinoma stained with anti-TS antibody

Human Bladder Transitional Cell Carcinoma stained with anti-TS antibody

Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody

Human Tonsil stained with anti-TS antibody

Human Colorectal Adenocarcinoma stained with anti-TS antibody

Human Bladder Transitional Cell Carcinoma stained with anti-TS antibody

Human Hepatocellular Carcinoma stained with anit-TS antibody

Human Lung SCCa stained with anti-TS antibody

Human Lymph Node stained with anti-TS antibody

Human B Cell Lymphoma stained with anti-TS antibody

Human Hepatocellular Carcinoma stained with anit-TS antibody

Human Lung SCCa stained with anti-TS antibody

Human Lymph Node stained with anti-TS antibody

Human B Cell Lymphoma stained with anti-TS antibody

Human Ovarian Adenocarcinoma stained with anti-TS antibody

Human Pancreatic Adenocarcinoma stained with anti-TS antibody

Human Stomach Adenocarcinoma stained with anti-TS antibody

Human Ovarian Adenocarcinoma stained with anti-TS antibody

Human Pancreatic Adenocarcinoma stained with anti-TS antibody

Human Stomach Adenocarcinoma stained with anti-TS antibody

Product Details:

 

Technology

Rabbit Monoclonal

Clone Name

SP112

Application

IHC-P

Species Reactivity

  

   Tested

Hu

   Predicted by homology

Bv, Fg, Ms, Rb, Rt

Isotype

Rabbit IgG

Immunogen

Synthetic peptide near C-terminus of human TS.

Cellular Localization

Cytoplasm, Nucleus

Control Tissue

Colon Carcinoma, Tonsil

Regulatory Rating

Research Use Only (RUO)

Entrez

7298

Storage Requirement

2-8°C

Target Molecular Weight

36 kDa

Formulation

Refer to Data Sheet