Rabbit Anti-Human Thymidylate Synthase (TS) Monoclonal Antibody (Clone SP112)

For research use only. Not for use in diagnostics.

Product No.	Pack Size
06973183001	0.1 mL

Product No.	Pack Size
06973213001	1.0 mL

To order these products, please contact your Roche order management team.

Keywords: Antibodies, Rabbit Monoclonal

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma. **Please contact us for availability**

Figure above:
Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

IHC Performance


Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody	Human Tonsil stained with anti-TS antibody	Human Colorectal Adenocarcinoma stained with anti-TS antibody	Human Bladder Transitional Cell Carcinoma stained with anti-TS antibody

Human Hepatocellular Carcinoma stained with anit-TS antibody	Human Lung SCCa stained with anti-TS antibody	Human Lymph Node stained with anti-TS antibody	Human B Cell Lymphoma stained with anti-TS antibody

Human Ovarian Adenocarcinoma stained with anti-TS antibody	Human Pancreatic Adenocarcinoma stained with anti-TS antibody	Human Stomach Adenocarcinoma stained with anti-TS antibody

Product Details:

Technology	Rabbit Monoclonal
Clone Name	SP112
Application	IHC-P
Species Reactivity
Tested	Hu
Predicted by homology	Bv, Fg, Ms, Rb, Rt
Isotype	Rabbit IgG
Immunogen	Synthetic peptide near C-terminus of human TS.
Cellular Localization	Cytoplasm, Nucleus
Control Tissue	Colon Carcinoma, Tonsil
Regulatory Rating	Research Use Only (RUO)
Entrez	7298
Storage Requirement	2-8°C
Target Molecular Weight	36 kDa
Formulation	Refer to Data Sheet

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