Rabbit Anti-Human Thymidylate Synthase (TS) Monoclonal Antibody (Clone SP112)
For research use only. Not for use in diagnostics.
Product No. | Pack Size |
---|---|
06973183001 | 0.1 mL |
Product No. | Pack Size |
---|---|
06973213001 | 1.0 mL |
To order these products, please contact your Roche order management team.
Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma. **Please contact us for availability**
Figure above:
Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody
Contents
Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
IHC Performance
Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody |
Human Tonsil stained with anti-TS antibody |
Human Colorectal Adenocarcinoma stained with anti-TS antibody |
Human Bladder Transitional Cell Carcinoma stained with anti-TS antibody |
Human Hepatocellular Carcinoma stained with anit-TS antibody |
Human Lung SCCa stained with anti-TS antibody |
Human Lymph Node stained with anti-TS antibody |
Human B Cell Lymphoma stained with anti-TS antibody |
Human Ovarian Adenocarcinoma stained with anti-TS antibody |
Human Pancreatic Adenocarcinoma stained with anti-TS antibody |
Human Stomach Adenocarcinoma stained with anti-TS antibody |
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP112 |
Application |
IHC-P |
Species Reactivity |
|
Tested |
Hu |
Predicted by homology |
Bv, Fg, Ms, Rb, Rt |
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide near C-terminus of human TS. |
Cellular Localization |
Cytoplasm, Nucleus |
Control Tissue |
Colon Carcinoma, Tonsil |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
7298 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
36 kDa |
Formulation |
Refer to Data Sheet |