Rabbit Anti-Human URI Monoclonal Antibody (Clone SP215)

Unconventional prefoldin RPB5 interactor (URI) is an oncogene required for the survival of some human carcinomas and is often amplified and over-expressed in subsets of carcinomas from ovary, breast, stomach, and lung. Activation of URI contributes an important mechanism for activating mitochondrial S6K1-BAD signaling and promoting cell survival through disabling PP1γ-dependent negative feedback inhibition. URI can negatively modulate RNA polymerase II subunit 5 (RPB5) and mediates resistance of cells to cisplatin.

Figure above:
Human ovarian adenocarcinoma stained with anti-URI antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.