Rabbit Anti-Human URI Monoclonal Antibody (Clone SP215)
For research use only. Not for use in diagnostics.
Product No. | Pack Size |
---|---|
07070314001 | 0.1 mL |
Product No. | Pack Size |
---|---|
07070969001 | 1.0 mL |
To order these products, please contact your Roche order management team.
Unconventional prefoldin RPB5 interactor (URI) is an oncogene required for the survival of some human carcinomas and is often amplified and over-expressed in subsets of carcinomas from ovary, breast, stomach, and lung. Activation of URI contributes an important mechanism for activating mitochondrial S6K1-BAD signaling and promoting cell survival through disabling PP1γ-dependent negative feedback inhibition. URI can negatively modulate RNA polymerase II subunit 5 (RPB5) and mediates resistance of cells to cisplatin.
Figure above:
Human ovarian adenocarcinoma stained with anti-URI antibody
Contents
Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
IHC Performance
Human Ovarian adenocarcinoma stained with anti-URI antibody |
Flow Cytometric Analysis
Flow cytometric analysis of rabbit anti-URI (SP215) antibody in 293 (green) compare to negative control of rabbit IgG (blue)
Product Details:
Technology |
Rabbit Monoclonal |
Clone Name |
SP215 |
Application |
IHC-P, FACS |
Species Reactivity |
|
Tested |
Hu |
Predicted by homology |
Bv, Ms |
Isotype |
Rabbit IgG |
Immunogen |
Synthetic peptide derived from the C-terminus of the human URI protein. |
Cellular Localization |
Cytoplasm, Nucleus |
Control Tissue |
Ovarian Carcinoma |
Regulatory Rating |
Research Use Only (RUO) |
Entrez |
8725 |
Storage Requirement |
2-8°C |
Target Molecular Weight |
57 kDa |
Formulation |
Refer to Data Sheet |