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nucleic acids and proteins. The resulting supernatant is suitable for subsequent purification, extraction, or analysis using either the MagNA Pure LC Instruments or the MagNA Pure Compact Instrument.
Recommended MagNA Lyser speed and run time settings are provided in many of the MagNA Pure LC and MagNA Compact pack inserts. After tissue and lysis reagents are added to the sample tubes, the instrument disrupts tissues and cells using rapid, oscillating agitation. There is no need to use additional lysing enzymes or mechanical grinding tools.
The MagNA Lyser Instrument and MagNA Lyser Green Beads can also be used with non-Roche lysis buffers that have been evaluated for tissue homogenization and the stabilization of nucleic acids. When using the instrument and ceramic beads with such lysis buffers, it will be necessary to test various speed and run times to optimize tissue homogenization.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Additional Equipment and Reagent Required", "Value": "

• MagNA Lyser Instrument
• MagNA Lyser Rotor Cooling Block (additional cooling block for increased throughput)
• MagNA Lyser Rotors (two additional rotors for increased throughput)
• MagNA Pure LC 2.0 Instrument (nucleic acid purfication robot for up to 32 samples)
• MagNA Pure Compact Instrument (nucleic acid purfication robot for up to 8 samples

", "Language": "en", "Country": "XG", "Code": "Additional Equipment and Reagent Required" }, { "Name": "Applications", "Value": "The MagNA Lyser Green Beads (tubes prefilled with ceramic beads) are specially designed for use in the MagNA Lyser Instrument to achieve optimal homogenization of various sample materials (e.g., tissue, plant tissue, cells). The ceramic beads can be used with the optimized lysis buffers of the MagNA Pure LC reagent kits for nucleic-acid extraction with the MagNA Pure LC Instrument.", "Language": "en", "Country": "XG", "Code": "Applications" }, { "Name": "Principle", "Value": "The MagNA Lyser Instrument is a benchtop device, that in combination with MagNA Lyser Green Beads and lysis buffers found in either MagNA Pure LC and MagNA Pure Compact isolation kits, automatically disrupts cells or other biological materials. The instrument facilitates the production of a supernatant containing nucleic acids and proteins suitable for subsequent purification, extraction, or analysis. The MagNA Lyser Instrument is to be used exclusively by laboratory professionals trained in laboratory techniques using the instructions provided in the MagNA Lyser Operator's Manual.

The principle underlying cell disruption is the fast moving, oscillating reciprocal motion of the MagNA Lyser Instrument Rotor holding sample tubes containing ceramic beads, tissue, and lysis buffers. This rapid disruptive motion provides optimal conditions for homogenizing mammalian tissue, plant tissue, bacterial cells, yeast, or other cellular material. There is no need to use additional lysing enzymes or mechanical grinding tools.

Cellular homogenization during a MagNA Lyser Instrument run is caused by the collision of ceramic beads with tissue and cells in the presence of the appropriate lysis buffer. Both the rate of collision and energy of impact determine the effectiveness of the disruption process. Variable instrument speed and run time settings permit the appropriate amount of homogenization required for a specific application. Please refer to the package insert of the specific MagNA Pure LC or MagNA Pure Compact DNA, RNA, and mRNA isolation kits from tissues for recommended MagNA Lyser speed settings and run times.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Description", "Value": "MagNA Lyser Green Beads are supplied in 2-ml screw-capped tubes, prefilled with 1.4-mm (diameter) ceramic beads. These tubes are specifically designed for use with MagNA Pure LC lysis buffers (for isolating DNA or RNA) and the MagNA Lyser Instrument to quickly and completely homogenize a variety of solid cellular sample materials, such as bacteria, fungi, and animal and plant tissues and cells.", "Language": "en", "Country": "XG", "Code": "Product Description" }, { "Name": "Content", "Value": "2 ml screw-cap tubes prefilled with 1.4 mm ceramic beads.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Product Purpose", "Value": "MagNA Lyser Green Beads are supplied in 2-ml screw-capped tubes, prefilled with 1.4-mm (diameter) ceramic beads. These tubes are specifically designed for use with MagNA Pure LC lysis buffers (for isolating DNA or RNA) and the MagNA Lyser Instrument to quickly and completely homogenize a variety of solid cellular sample materials, such as bacteria, fungi, and animal and plant tissues and cells.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }