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MagNA Pure 24 Instrument

A fully-automated clinical nucleic acid extraction system that brings you walkaway automation for up to 24 samples.

For in vitro diagnostic use.

Product No. Pack Size
07290519001 1 instrument, built-in control unit, and accessories

To order these products, please contact your Roche order management team.

The MagNA Pure 24 System purifies nucleic acids from a wide range of starting materials using magnetic glass particle technology. The MagNA Pure 24 System builds on the legacy of the MagNA Pure automated nucleic acid extraction systems and processes up to 24 samples in just over an hour using barcoded, prefilled cassettes with ready-to-use reagents.

Preprogrammed software protocols are tailored to a diversity of prevalidated human sample types. The isolated and purified nucleic acids meet the quality standards required for genomic workflows such as highly sensitive quantitative PCR/RT-PCR analysis.

This system enhances your nucleic acid isolation workflow with easy-to-use features such as mixed-sample batching for multiple downstream applications, plus;

  • Scalable extraction of 1-24 samples with primary sample handling in 70 minutes
  • A single universal reagent kit covering 10 prevalidated human samples types, with volume inputs ranging 200 µL to 4 mL
  • Inventory and sample tracking
  • True walkaway automation with safety surveillance features
  • Seamless data management using intuitive features, such as the link to a laboratory information management system (LIMS).

The MagNA Pure 24 System gives you the flexibility to extract up to 10 different human sample types with a single universal reagent kit. Rely on this simplified reagent concept and choose one of the pre-optimized and pre-programmed protocols to extract from mixed batch sample types and primary tubes within one protocol. Please refer to the MagNA Pure 24 protocol download instructions found here.

 Target: Bacterial, fungal, and Viral NA
Protocol Name  Input sample type and sample volumes Elution Volume
 Whole Blood   Plasma   Serum  Nasal   Swabs‡   BAL§ 
 Urine   Stool   Cultured  Cells  Fresh Frozen Tissue

Pathogen 200  
Protocol optimized for speed

200 μL 200 μL 200 μL 200 μL 200 μL 200 μL 200 μL     50 or
100 μL

Pathogen 200 hp*  
Protocol optimized for yield and purity

200 μL
200 μL
200 μL
200 μL
200 μL
200 μL
200 μL
    50 or
100 μL

Fast Pathogen 200* 
8 sample protocol optimized for speed, yield and purtity

200 μL
200 μL
200 μL
200 μL
200 μL
200 μL
200 μL
    50 or
100 μL

Pathogen 1000 
Protocol optimized for yield and purity

500 or
1000 μL
500 or
1000 μL
500 or
1000 μL
500 or
1000 μL
500 or
1000 μL
500 or
1000 μL
500 or
1000 μL
    50 or
100 μL
External Lysis Pathogen 200* 
Protocol optimized with external lysis buffer
200 μL
200 μL
200 μL
            50 or
100 μL
External Lysis Pathogen 500* 
Protocol optimized with external lysis buffer
500 μL
500 μL 500 μL             50 or
100 μL
*New Protocols
Nasal Swabs=Nasopharyngeal/nasal swabs
§BAL=Bronchoalveolar Lavage
 Target: Genomic DNA
Protocol Name  Input sample type and sample volumes  Elution Volume 
 Whole Blood  Plasma  Serum Nasal  Swabs  BAL§
 Urine  Stool  Cultured  Cells Fresh Frozen Tissue

hgDNA 200
Protocol optimized for human genomic NA

200 μL             1 Up to
5 mg
50 or
100 μL

Fast hgDNA 200
8 sample protocol optimized for speed

200 μL             1   50 or
100 μL
hgDNA ds 200*
Protocol optimized for NGS

200 μL

            1   50 or
100 μL

hgDNA 1000
Protocol optimized for yield and purity

500 or
1000 μL
            2   100 or
200 μL
*New Protocols
Nasal Swabs=Nasopharyngeal/nasal swabs
§BAL=Bronchoalveolar Lavage
1 Up to 5x105 cultured cells
2 Up to 1x106 cultured cells
 Target: Cell-free NA
Protocol Name  Input sample type and sample volumes  Elution Volume
 Whole  Blood  Plasma   Serum Nasal Swabs‡   BAL§ 
 Urine  Stool  Cultured  Cells Fresh Frozen Tissue

cfNA ss 2000
Protocol optimized for single-stranded DNA

  2000 μL               50 or 100 μL

cfNA ss 4000
Protocol optimized for single-stranded DNA

  4000 μL               50 or 100 μL

cfNA ds 2000
Protocol optimized for double-stranded DNA

  2000 μL               100, 150 or 200 μL

cfNA ds 4000
Protocol optimized for double-stranded DNA

  4000 μL               100, 150 or 200 μL

cfNA ds 4000 hp*
Protocol optimized for double-stranded DNA and NGS

 
4000 μL
              60 or 150 μL
*New Protocols
Nasal Swabs=Nasopharyngeal/nasal swabs
§BAL=Bronchoalveolar Lavage
 Target: Post Elution
Protocol Name  Input sample type and sample volumes  Elution Volume
 Whole  Blood  Plasma   Serum  Nasal Swabs‡   BAL§ 
 Urine  Stool  Cultured  Cells Fresh Frozen Tissue

Sample Transfer to the processing cartridge  

200, 500
or
1000 μL
200, 500
or
1000 μL
200, 500
or
1000 μL
200, 500
or
1000 μL
200, 500
or
1000 μL
200, 500
or
1000 μL
200, 500
or
1000 μL
200, 500
or
1000 μL
   

PCR Setup for 2-25 μL per eluate for PCR Setup in FrameStrip with flat caps-Low Profile or LightCycler® 8-tube strips  

                   

Archiving for 25-50 μL per eluate FrameStrip low profile strips, or LightCycler® 8-tube strips  

                   
Nasal Swabs=Nasopharyngeal/nasal swabs
§BAL=Bronchoalveolar Lavage


Magnetism is used for automated nucleic acid isolation performed by the MagNA Pure 24 System. Magnetic glass particles (MGPs) are used to isolate RNA, DNA and total nucleic acids (tNA) from a variety of different sample materials.

Table: Key specifications of the MagNA Pure 24 System:

 

Sample Number:

1 to 24 isolations per run

Sample Volume:

input of 200 µL to 4 mL

Ability to mix batch within one run:

yes

Validated human sample types:

whole blood, plasma, serum, sputum, swabs, broncho alveolar lavage, urine, cerebrospinal fluid, stool, fresh or frozen tissue

Run time for 24 isolations:

approx. 70 minutes for 200 µL starting sample volume

Run time for 8 isolations:

approx. 30 minutes for 200 µL starting sample volumes

Reagent type:

universal, prefilled, ready-to-use cassettes

LIMS connectivity:

yes

21CFR part 11 (subsection B) compatibility:

yes

Labeling:

CE-IVD (EU), IVD (US)

 

The MagNA Pure 24 System is currently on software version 1.0.

If you need assistance to update your system software, please contact your local Roche representative.

MagNA Pure 24 System Technical Video