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MagNA Pure 24 Instrument

A fully-automated clinical nucleic acid extraction system that brings you walkaway automation for up to 24 samples.

For in vitro diagnostic use.

Product No. Pack Size
07290519001 1 instrument, built-in control unit, and accessories

To order these products, please contact your Roche order management team.

The MagNA Pure 24 System purifies nucleic acids from a wide range of starting materials using magnetic glass particle technology. The MagNA Pure 24 System builds on the legacy of the MagNA Pure automated nucleic acid extraction systems and processes up to 24 samples in just over an hour using barcoded, prefilled cassettes with ready-to-use reagents.

Preprogrammed software protocols are tailored to a diversity of prevalidated human sample types. The isolated and purified nucleic acids meet the quality standards required for genomic workflows such as highly sensitive quantitative PCR/RT-PCR analysis.

This system enhances your nucleic acid isolation workflow with easy-to-use features such as mixed-sample batching for multiple downstream applications, plus;

  • Scalable extraction of 1-24 samples with primary sample handling in 70 minutes
  • A single universal reagent kit covering 10 prevalidated human samples types, with volume inputs ranging 200 µL to 4 mL
  • Inventory and sample tracking
  • True walkaway automation with safety surveillance features
  • Seamless data management using intuitive features, such as the link to a laboratory information management system (LIMS).

For nearly two decades, molecular testing laboratories have trusted the MagNA Pure family in providing automated extraction solutions, offering a superior start to their genomic workflow. We have streamlined the purification process to one universal reagent kit complemented by a very small number of consumables and handling steps.

The MagNA Pure 24 System is a low- to medium-throughput instrument for automated nucleic acid purification. The diversity of purification protocols and the pre-validated sample support with our ready-to-use reagent enable application flexibility while still being easy-to-use.

In addition, optimized preprogrammed purification protocols ensure routine sample handling and high quality, reproducible nucleic acid yields. Choose the appropriate purification protocol for your sample material and target nucleic acid:

Table: List of the purification protocols pre-programmed on the MagNA Pure 24 System

Protocol Name

Target Material

Sample Material

Starting Volume

 Pathogen 200

Bacterial DNA/ Viral NA

whole blood, plasma, serum or material of human origin

  • 200 µL

 Pathogen 1000

  • 500 µL or 1000 µL

 hgDNA 200

Genomic DNA

whole blood, cultured cells, fresh-frozen tissue

  • 200 µL
  • up to 5x105 cultured cells
  • up to 5 mg of fresh-frozen tissue

 hgDNA 1000

whole blood

  • 500 µL or 1000 µL
  • up to 1x10cultured cells
  • up to 5 mg of fresh-frozen tissue

 hgDNA Fast 200

whole blood, cultured cells

  • 200 µL, up to 5x105cultured cells

 cfNA ss 2000

nucleic acid

Plasma (collected in Roche cell-free DNA,
K2-EDTA and Streck Cell-Free DNA BCT Tubes)

  • 2 mL

 cfNA ds 2000

  • 2 mL

 cfNA ss 4000

  • 4 mL

 cfNA ds 4000

  • 4 mL

Magnetism is used for automated nucleic acid isolation performed by the MagNA Pure 24 System. Magnetic glass particles (MGPs) are used to isolate RNA, DNA and total nucleic acids (tNA) from a variety of different sample materials.

Table: Key specifications of the MagNA Pure 24 System:


Sample Number:

1 to 24 isolations per run

Sample Volume:

input of 200 µL to 4 mL

Ability to mix batch within one run:


Validated human sample types:

whole blood, plasma, serum, sputum, swabs, broncho alveolar lavage, urine, cerebrospinal fluid, stool, fresh or frozen tissue

Run time for 24 isolations:

approx. 70 minutes for 200 µL starting sample volume

Run time for 8 isolations:

approx. 30 minutes for 200 µL starting sample volumes

Reagent type:

universal, prefilled, ready-to-use cassettes

LIMS connectivity:


21CFR part 11 (subsection B) compatibility:





The MagNA Pure 24 System is currently on software version 1.0.

If you need assistance to update your system software, please contact your local Roche representative.

MagNA Pure 24 System Technical Video