MagNA Pure 24 Instrument

A fully-automated clinical nucleic acid extraction system that brings you walkaway automation for up to 24 samples.

For in vitro diagnostic use.

Product No.	Pack Size
07290519001	1 instrument, built-in control unit, and accessories

To order these products, please contact your Roche order management team.

Keywords: Automated Isolation & Purification, MagNA Pure 24 Instrument, Instruments

The MagNA Pure 24 System purifies nucleic acids from a wide range of starting materials using magnetic glass particle technology. The MagNA Pure 24 System builds on the legacy of the MagNA Pure automated nucleic acid extraction systems and processes up to 24 samples in just over an hour using barcoded, prefilled cassettes with ready-to-use reagents.

Preprogrammed software protocols are tailored to a diversity of prevalidated human sample types. The isolated and purified nucleic acids meet the quality standards required for genomic workflows such as highly sensitive quantitative PCR/RT-PCR analysis.

This system enhances your nucleic acid isolation workflow with easy-to-use features such as mixed-sample batching for multiple downstream applications, plus;

Scalable extraction of 1-24 samples with primary sample handling in 70 minutes
A single universal reagent kit covering 9 prevalidated human samples types, with volume inputs ranging 200 µL to 4 mL
Inventory and sample tracking
True walkaway automation with safety surveillance features
Seamless data management using intuitive features, such as the link to a laboratory information management system (LIMS).

The MagNA Pure 24 System gives you the flexibility to extract a large variety of human sample types with a single universal reagent kit. Rely on this simplified reagent concept and choose one of the pre-optimized and pre-programmed protocols to extract from mixed batch sample types and primary tubes within one protocol. Please refer to the MagNA Pure 24 protocol download instructions found here.

Target: Bacterial, fungal and viral NA
Protocol name	Input sample type and sample volumes									Elution volume
Protocol name	Whole blood	Plasma	Serum	Nasal swabs^‡	BAL^§	Urine	Stool	Cultured cells	Fresh-frozen tissue	Elution volume
Pathogen 200 Protocol optimized for speed	200 μL	200 μL	200 μL	200 μL	200 μL	200 μL	200 μL			50 or 100 μL
Pathogen 200 hp* Protocol optimized for yield and purity	200 μL	200 μL	200 μL	200 μL	200 μL	200 μL	200 μL			50 or 100 μL
Fast Pathogen 200* 8 sample protocol optimized for speed, yield and purtity	200 μL	200 μL	200 μL	200 μL	200 μL	200 μL	200 μL			50 or 100 μL
Pathogen 1000 Protocol optimized for yield and purity	500 or 1000 μL	500 or 1000 μL	500 or 1000 μL	500 or 1000 μL	500 or 1000 μL	500 or 1000 μL	500 or 1000 μL			50 or 100 μL
External Lysis Pathogen 200* Protocol optimized with external lysis buffer	200 μL	200 μL	200 μL							50 or 100 μL
External Lysis Pathogen 500* Protocol optimized with external lysis buffer	500 μL	500 μL	500 μL							50 or 100 μL
*New Protocols ^‡Nasal swabs=Nasopharyngeal/nasal swabs ^§BAL=Bronchoalveolar Lavage

Target: Genomic DNA
Protocol name	Input sample type and sample volumes									Elution volume
Protocol name	Whole blood	Plasma	Serum	Nasal swabs^‡	BAL^§	Urine	Stool	Cultured cells	Fresh-frozen tissue	Elution volume
hgDNA 200 Protocol optimized for human genomic NA	200 μL							●¹	Up to 5 mg	50 or 100 μL
Fast hgDNA 200 8 sample protocol optimized for speed	200 μL							●¹		50 or 100 μL
hgDNA ds 200* Protocol optimized for NGS	200 μL							●¹		50 or 100 μL
hgDNA 1000 Protocol optimized for yield and purity	500 or 1000 μL							●²		100 or 200 μL
*New Protocols ^‡Nasal swabs=Nasopharyngeal/nasal swabs ^§BAL=Bronchoalveolar Lavage					●¹ Up to 5x10⁵ cultured cells ●² Up to 1x10⁶ cultured cells

Target: Cell-free NA
Protocol name	Input sample type and sample volumes									Elution volume
Protocol name	Whole blood	Plasma	Serum	Nasal swabs^‡	BAL^§	Urine	Stool	Cultured cells	Fresh-frozen tissue	Elution volume
cfNA ss 2000 Protocol optimized for single-stranded DNA		2000 μL								50 or 100 μL
cfNA ss 4000 Protocol optimized for single-stranded DNA		4000 μL								50 or 100 μL
cfNA ds 2000 Protocol optimized for double-stranded DNA		2000 μL								100, 150 or 200 μL
cfNA ds 4000 Protocol optimized for double-stranded DNA		4000 μL								100, 150 or 200 μL
cfNA ds 4000 hp* Protocol optimized for double-stranded DNA and NGS		4000 μL								60 or 150 μL
*New Protocols ^‡Nasal swabs=Nasopharyngeal/nasal swabs ^§BAL=Bronchoalveolar Lavage

Target: Post elution
Protocol name	Input sample type and sample volumes									Elution volume
Protocol name	Whole blood	Plasma	Serum	Nasal swabs^‡	BAL^§	Urine	Stool	Cultured cells	Fresh-frozen tissue	Elution volume
Sample Transfer to the processing cartridge	200, 500 or 1000 μL	200, 500 or 1000 μL	200, 500 or 1000 μL	200, 500 or 1000 μL	200, 500 or 1000 μL	200, 500 or 1000 μL	200, 500 or 1000 μL	200, 500 or 1000 μL
PCR Setup for 2-25 μL per eluate for PCR Setup in FrameStrip with flat caps-Low Profile or LightCycler^® 8-tube strips
Archiving for 25-50 μL per eluate FrameStrip low profile strips, or LightCycler^® 8-tube strips
^‡Nasal swabs=Nasopharyngeal/nasal swabs ^§BAL=Bronchoalveolar Lavage

Magnetism is used for automated nucleic acid isolation performed by the MagNA Pure 24 System. Magnetic glass particles (MGPs) are used to isolate RNA, DNA and total nucleic acids (tNA) from a variety of different sample materials.

Table: Key specifications of the MagNA Pure 24 System:

Sample Number:	1 to 24 isolations per run
Sample Volume:	input of 200 µL to 4 mL
Ability to mix batch within one run:	yes
Validated human sample types:	whole blood, plasma, serum, nasal swab, BAL, urine, stool, cultured cells, fresh-frozen tissue
Run time for 24 isolations:	approx. 70 minutes for 200 µL starting sample volume
Run time for 8 isolations:	approx. 30 minutes for 200 µL starting sample volumes
Reagent type:	universal, prefilled, ready-to-use cassettes
LIMS connectivity:	yes
21CFR part 11 (subsection B) compatibility:	yes
Labeling:	CE-IVD (EU), IVD (US)

The Magna Pure 24 system is on software version 1.1 currently.

View the archived database with the Archive Viewer.

If you need assistance to update your system software, please contact your local Roche representative.

MagNA Pure 24 System Technical Video

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